titrate 25 cm 3 of this solution against 0.10 M hydrochloric acid
The reasons for these 32 repeated titrations were excessive leakage in 20 cases and a registration period under 6 hours or a sleep time under 5 hours (subjectively appreciated by the patient) in the remaining 12 cases.
Aliquots of the peptide solution were titrated to the micelle solution to reach a peptide-to-micelle molar ratio of 1: 220.
The only extra hydrogen bond that is formed involving titratable residues is between OG1 and OE2.
The sign and magnitude of the pK a shift of a particular titratable group is determined by the free energy to transfer it into the low-dielectric protein cavity, and by its interactions with polar residues in the protein.
Thus, it is reasonable to assume that the protonation of the titratable residues on the HA1 surface is mainly influenced by other residues of HA1 and that effects from HA2 domain may be negligible.
A specific weight of the compound is titrated with a known concentration of acid or base until the equivalence point has been reached.
Symptoms include abdominal discomfort, metallic taste, nausea, and diarrhea; these effects are generally transient and can be minimized by taking the drug with meals and titrating the dose slowly.
Generally, a longer-acting benzodiazepine such as chlordiazepoxide is used, and the initial dosage is titrated downward according to blood pressure elevation, pulse rate, temperature and psychotic symptoms.
So if Plotkin is correct when he says that the titration was done in Philadelphia, this would mean that the vaccine fed in Africa was of unknown titre.