The reactive epithelium may extend into the superficial reticular dermis , simulating a carcinoma.
The thicker or inner layer of the dermis contains blood vessels, hair follicles, nerve endings, sweat and sebaceous glands.
Mitotic figures are variably present, and tumor aggregates may extend into the reticular dermis or even subcutaneous fat.
The biopsy should include surrounding skin with underlying dermis and connective tissue so that the pathologist can evaluate the depth of stromal invasion.
Although it is composed of two primary layers, the outer epidermis and the inner dermis , it also contains arteries, veins, nerve fibers, sweat glands and hair follicles among other things.
Cigarettes independently damage the elastic fibers of the dermis and promote elastosis similar to that found in sun-exposed skin.
Occasionally, the upper reticular dermis also may be infiltrated, but by isolated single cells.
The dermal-epidermal junction, papillary dermis, and reticular dermis were assessed separately.
The epidermis is devoid of blood vessels but is nourished by diffusion from capillaries in the underlying dermis .
The middle layer, or dermis , contains connective tissue, small blood vessels, sweat and oil glands, nerves, and cells that produce collagen, called fibroblasts.