Some experimental evidence on animals with artificially induced fevers supports the possibility of its antipyretic effects.
The antipyretic and analgesic drug acetaminophen is safe in the therapeutic range, but an overdose often causes severe hepatotoxicity in experimental animals and humans.
The infection resolves spontaneously in 7-14 days, during which antipyretic analgesics such as paracetamol and adequate hydration are helpful.
A response to antipyretic medication does not change the likelihood of a child having serious bacterial infection and should not be used for clinical decision-making.
The third point is the use of intermittent antipyretic treatment to prevent future febrile seizures.
The authors conclude that acetaminophen and ibuprofen have similar analgesic effects in relieving moderate to severe pain, but ibuprofen has better antipyretic properties.
Animal research found antipyretic effects of phytosterols were comparable to that of aspirin.
Based on this data, it is recommenced that febrile episodes not be routinely treated with antipyretic therapy; an evaluation of the relative benefits and risks of antipyretic treatment should be evaluated in each individual case.
This is most likely a rebound effect as the antipyretic effects subside.
Bitter Melon is known as an antipoison or antipyretic agent.